Issue 25March 2023
Special report

The tissue microbiota

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    The report in this issue lifts the veil on a microbiota that remains relatively unknown: The tissue microbiota.

    In the early 2010s, micro-organisms were identified in our tissues, including in the blood.This represented a break away from the globally accepted concept of a sterile internal environment. 

    This paradigm shift is now largely accepted. The composition of the tissue microbiota is specific to the tissue in which it is found.It is fed by the translocation of bacteria, bacterial fragments or bacterial metabolites, namely from the gut to the tissues.It has thus been demonstrated that changes in the gut microbiota by the ingestion of prebiotics or probiotics, or via a faecal transplantation altering the tissue microbiota.Differences in the composition of the tissue microbiota have been described in patients suffering from pathologies namely of a cardiovascular, metabolic or cancerous nature.In this regard, the blood microbiota could be a source of biomarkers for the prediction of such cardiovascular, metabolic or cancerous conditions.Furthermore, it has been shown that the microbiota of cancerous tissue influences the prognosis of the disease. This impact is explained by the influence of the tumour microbiota on the immune response.

    Related to this topic, in this issue (in the Interview section),Professor Pascal Hammel spoke to us about the impact of  microbiota in pancreatic cancer. In short, the identification and modulation of the tissue microbiota opened up new diagnosis and therapeutic pathways for human healthcare, which we should continue to explore.

    Happy reading!

    Jacques Amar
    Editor in Chief of this issue

    Table of contents

    • Special Report

    • Interview

      • Pascal Hammel
        Contributors : Pascal HAMMEL
    • In Brief

    • Microbiota News

      • Long Covid or Post-Covid-19 syndrome: Further ambiguity…
        Scientific committee : Jean-Marc Bohbot
    • Microbiota News

      • A meta-analysis confirms the interest in probiotics for obesity
        Scientific committee : Philippe Gérard
      • Short bowel syndrome: Analysing bile acids to make dietary adaptations
        Scientific committee : Stanislas Bruley des Varannes
      • Reinforced colic preparations prior to faecal transplantation in controlling haemorrhagic recto-colitis
        Scientific committee : Stanislas Bruley des Varannes
      • Correlation between dysbiosis and anaphylactic severity
        Scientific committee : Cyrille Hoarau
      • Influence of diet on the immune system via the gut microbiota: A trans-generational effect
        Scientific committee : Alexis Mosca
    • Focus

      • Cardiology - Moving towards the regulation of high blood pressure via the gut microbiota?
        Scientific committee : Jacques Amar
      • Gynaecology - Impact of vaginal dysbiosis in provoked vestibulodynia (PVD)
        Scientific committee : Jean-Marc Bohbot
      • Metabolism - Mums-to-be: Eat healthily!
        Scientific committee : Bruno Pot
      • Metabolism - First steps towards oral microbiotherapy in C. Diff. Colitis
        Scientific committee : Geneviève Héry-Arnaud
      • Oncology - A connection established between Western diets, intestinal bacteria and colorectal cancer
        Scientific committee : Philippe Gérard
      • Paediatrics - Gut microbiota and vaccine response: Promising pistes
        Scientific committee : Alexis Mosca
    • Taxonomic Reference


    • Interview

      Prof. Pascal HAMMEL

      Department of Digestive and Medical Oncology, Paul-Brousse Hospital, Villejuif

    Scientific committee

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