Issue 21 october 2021 Special Report Innate immunity and microbiota

Numéro 21 - Innate immunity and microbiota
Download for free

Although Elie Metchnikoff studied the link between the good health, diet and flora of certain populations (see The Microbiota Chronicle p .15), immunity, or the idea of immunity, was deeply marked by Pasteur's vision; microbes are considered to be "harmful" and the main purpose of immunity is to eliminate them.

Since the 1950s, research efforts have focused particularly on adaptive immunity, ultimately presented as the final stage of the evolution of the immune system. During this period, when the microbe was the enemy and theories drawn from Pasteur were applied at a clinical level, infectious diseases saw significant regression, a commendable outcome. But paradoxically, the incidence of immune disorders such as inflammatory diseases, allergies, diabetes and other autoimmune diseases has exploded.

It was in the 1980s that the hygiene hypothesis advanced the link between immune disorders and the microbiota. But it was the progress of analytical tools, the discovery of innate immunity receptors (PRR) capable of recognizing the conserved patterns of microbes, and the use of germfree mouse models that demonstrated the major role of the microbiota in the development and control of immunity and its ability to adapt to the environment. Our view of immunity has therefore evolved into one of a system whose goal is to seek balance between an external and internal environment, and in which the microbiota is a primary interface for communication, exchange, regulation and, consequently, balance. The view of adaptive immunity has also evolved from a system “supplanting” innate immunity to a system that is in fact an “effector” of innate immune response. The special report that we present today illustrates the essential role of the microbiota and innate immunity in immune homeostasis and the interview with Dr. Jehane  Fadlallah, whom I thank, completes this feature by focusing more specifically on adaptive immunity.

I hope you enjoy reading it.


Cyrille Hoarau
Editor in chief of this issue

Read more

Table of contents

Special Report

  • Innate immunity and microbiota: the story of a key link to immune homeostasisCyrille Hoarau


  • Jehane Fadlallah

In Brief

The Microbiota Chronicle

  • Believe and trust in the science: the legacy of Élie Metchnikoff Bruno Pot

Microbiota News

  • Interesting Abstracts: A new milestone in understanding the role of gut microbiota in the pathogenesis of childhood asthmaAlexis Mosca
  • Lactobacillus gasseri LA806 in irritable bowelStanislas Bruley des Varannes
  • What will the next generation of probiotics look like?Bruno Pot


  • Cardiology: Eat (well) to liveJacques Amar
  • Gastroenterology:Faecal microbiota transplantation: encouraging data in cachectic patients with cancerStanislas Bruley des Varannes
  • Metabolism: Robust associations between gut microbiota, dietary habits and cardiometabolic healthPhilippe Gérard
  • Paediatrics: Bifidobacterium infantisE : a key species in the development of the gut microbiota in neonates?Alexis Mosca
  • Gynaecology and Obstetrics: Endometriosis: new data to support the existence of dysbiosis of several microbiotasJean-Marc Bohbot
  • Pulmonology: Educating the pulmonary innate immune system involves microbiotaGeneviève Héry-Arnaud
  • Neuropsychiatriy: The gut microbiota: a future biomarker for multiple sclerosis?Patrick Vermersch

Taxonomic Reference


Dossier thématiqueCyrille Hoarau

MD, PhD. Immunologist and allergy specialist, Interdisciplinary Unit of Clinical Immunology and Allergy Studies, Regional and University Hospital, Tours

EntretienJehane Fadlallah

Internal Medicine. Clinical Immunology, Saint-Louis Hospital, Paris.


LoginFor free access to all issues & a notification upon publication of each new issue

Forgotten password ?

Password requestHave you forgotten your password? Enter your email address and we will send you a message with the password reset procedure.


Not yet registered ?

Create an account free of charge

Create an accountFor free access to all issues & a notification upon publication of each new issue

If you wish to subscribe to the paper version of La Revue des Microbiotes and have it delivered to your door, please contact our Subscription Department:

  • ?
  • As a result, I accept that my email address will be forwarded to the company PILEJE (SAS – French simplified joint stock company – with a capital of €1,190,400,00 - registered at the companies register in Paris under the number 950 450 452 – 37, Quai de Grenelle, 75738 PARIS Cedex 15)

The information included in this form is intended for the company LARENA, responsible for processing, for the purposes of processing your request and managing our relationship.

In accordance with French law no. 78-17 of 6 January 1978, as amended, and European Regulation 2016/679 of 27 April 2016, you have the right to access, correct, restrict or delete data concerning you or exercise your right to opposition or right to portability. You can exercise these rights by making a request in writing, accompanied by proof of identity, to LARENA – DPO – 1 ZI du Taillis – Champtoceaux – 49270 Orée d’Anjou, France or to

For more information about the management of your personal data

*These fields are required to process your request. Without this information, we will be unable to process your request .

Already registered


Sample copyAccess the first issue free of charge without creating an account

Numéro 1 - Microorganisms and mankind
5 years of La Revue des Microbiotes !Watch the video