Issue 25 march 2023 Special Report The tissue microbiota
The report in this issue lifts the veil on a microbiota that remains relatively unknown: The tissue microbiota.
In the early 2010s, micro-organisms were identified in our tissues, including in the blood. This represented a break away from the globally accepted concept of a sterile internal environment.
This paradigm shift is now largely accepted. The composition of the tissue microbiota is specific to the tissue in which it is found. It is fed by the translocation of bacteria, bacterial fragments or bacterial metabolites, namely from the gut to the tissues. It has thus been demonstrated that changes in the gut microbiota by the ingestion of prebiotics or probiotics, or via a faecal transplantation altering the tissue microbiota. Differences in the composition of the tissue microbiota have been described in patients suffering from pathologies namely of a cardiovascular, metabolic or cancerous nature. In this regard, the blood microbiota could be a source of biomarkers for the prediction of such cardiovascular, metabolic or cancerous conditions. Furthermore, it has been shown that the microbiota of cancerous tissue influences the prognosis of the disease. This impact is explained by the influence of the tumour microbiota on the immune response.
Related to this topic, in this issue (in the Interview section), Professor Pascal Hammel spoke to us about the impact of microbiota in pancreatic cancer. In short, the identification and modulation of the tissue microbiota opened up new diagnosis and therapeutic pathways for human healthcare, which we should continue to explore.
Editor in Chief of this issue
Table of contents
- Pascal Hammel
- A meta-analysis confirms the interest in probiotics for obesityPhilippe Gérard
- Short bowel syndrome: Analysing bile acids to make dietary adaptationsStanislas Bruley des Varannes
- Reinforced colic preparations prior to faecal transplantation in controlling haemorrhagic recto-colitisStanislas Bruley des Varannes
- Correlation between dysbiosis and anaphylactic severityCyrille Hoarau
- Influence of diet on the immune system via the gut microbiota: A trans-generational effectAlexis Mosca
- Cardiology - Moving towards the regulation of high blood pressure via the gut microbiota?Jacques Amar
- Gynaecology - Impact of vaginal dysbiosis in provoked vestibulodynia (PVD)Jean-Marc Bohbot
- Metabolism - Mums-to-be: Eat healthily!Bruno Pot
- Metabolism - First steps towards oral microbiotherapy in C. Diff. ColitisGeneviève Héry-Arnaud
- Oncology - A connection established between Western diets, intestinal bacteria and colorectal cancerPhilippe Gérard
- Paediatrics - Gut microbiota and vaccine response: Promising pistesAlexis Mosca
EntretienPr Pascal HAMMEL
Department of Digestive and Medical Oncology, Paul-Brousse Hospital, Villejuif