Issue 22 march 2022 Special Report The genital microbiotas’ impact on fertility

Numéro 22 - The genital microbiotas’ impact on fertility
Download for free

Around 1 in 5 couples in France experiences fertility problems. In 75% of cases, an aetiology is found: female, male or mixed causes with a significant proportion of infectious aetiologies. Until recently, the focus has largely been on pathogenic bacteria.

However, in recent years, the study of host-microbiota interactions has led to the discovery of mechanisms  directly involving dysbioses in infertility. In particular, the notion of the existence of a continuum between the vaginal microbiota and the cervical and endometrial microbiota has provided a better understanding of the vaginal microbiota’s influence on the female upper genital tract. While it was recognised that vaginal dysbiosis favours colonisation of the upper genital tract with pathogenic bacteria, it is now shown that it also promotes the rise of commensal bacteria with a harmful effect on the endometrial mucosa.

The end of the microbiologically sterile sperm dogma has also changed our view of male fertility. While the composition of "normal" seminal microbiota remains controversial, we know that its alteration changes sperm quality and that once it reaches the vagina, the sperm’s quality can also be disrupted by the action of the vaginal microbiota.

These discoveries shed new light on the causes of infertility and implantation failures with medically-assisted reproduction protocols. The search for female and male genital dysbioses appears to be an  increasingly useful exploration for understanding the mechanisms of human infertility, with the prospect of new therapeutic pathways likely to be key. 

I hope you enjoy reading this issue.


Jean-Marc Bohbot,
Editor in Chief of this issue

Read more

Table of contents

Special Report


  • Blandine Courbiere

In Brief

The Microbiota Chronicle


  • Dermatology : Allowing bacteria to fight each other?Bruno Pot
  • Palaeontology : The microbiota as an aid to palaeomicrobiology Geneviève Héry-Arnaud
  • Environment : The cities also have their own microbiota!Philippe Gérard
  • Gastroenterology : Biofilms: a marker of irritable bowel?Stanislas Bruley des Varannes
  • Oncology - Cancer screening through blood microbiota analysis: a new paradigmJacques Amar
  • Oncology - Innate immunity in antitumour immune homoeostasis: a new demonstration of the major role of the microbiotaCyrille Hoarau
  • Paediatrics : Compensating for the negative effects of caesarean section on the newborn's gut microbiota: confirmed results for vaginal seedingAlexis Mosca
  • Neurology : Gut microbiota: a potential early marker of Parkinson's disease?Patrick Vermersch

Taxonomic Reference


EntretienProf. Blandine Courbiere

Clinical-Biological Centre for Medically-Assisted Reproduction - Women-Parent-Child Unit - Hôpital de La Conception, Marseilles. Thank you to Professor Courbiere who also reviewed the Special Report


LoginFor free access to all issues & a notification upon publication of each new issue

Forgotten password ?

Password requestHave you forgotten your password? Enter your email address and we will send you a message with the password reset procedure.


Not yet registered ?

Create an account free of charge

Create an accountFor free access to all issues & a notification upon publication of each new issue

If you wish to subscribe to the paper version of La Revue des Microbiotes and have it delivered to your door, please contact our Subscription Department:

  • ?
  • As a result, I accept that my email address will be forwarded to the company PILEJE (SAS – French simplified joint stock company – with a capital of €1,190,400,00 - registered at the companies register in Paris under the number 950 450 452 – 37, Quai de Grenelle, 75738 PARIS Cedex 15)

The information included in this form is intended for the company LARENA, responsible for processing, for the purposes of processing your request and managing our relationship.

In accordance with French law no. 78-17 of 6 January 1978, as amended, and European Regulation 2016/679 of 27 April 2016, you have the right to access, correct, restrict or delete data concerning you or exercise your right to opposition or right to portability. You can exercise these rights by making a request in writing, accompanied by proof of identity, to LARENA – DPO – 1 ZI du Taillis – Champtoceaux – 49270 Orée d’Anjou, France or to

For more information about the management of your personal data

*These fields are required to process your request. Without this information, we will be unable to process your request .

Already registered


Sample copyAccess the first issue free of charge without creating an account

Numéro 1 - Microorganisms and mankind
5 years of La Revue des Microbiotes !Watch the video