Issue 14 june 2019 Special Report Microbiota and HIV/AIDS

Numéro 14 - Microbiota and HIV/AIDS
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The gut microbiota’s impact on the onset of metabolic complications like obesity and diabetes, and neuropsychiatric disorders like autism has been widely described. However, fewer studies have been conducted on the involvement of the different microbiota in the susceptibility to and development of infectious diseases, although they represent an important field of research. Recent publications have, however, highlighted the gut microbiota’s role on the susceptibility to and severity of lung infections with Mycobacterium TuberculosisE. Moreover, several authors are investigating modulation of vaccine response by the gut microbiota, particularly with respect to oral vaccines. Antibiotics are also likely to have a significant impact on the dialogue between pathogens and commensal flora. The interactions between HIV infection and the gut microbiota represent a very specific field, and the impact of digestive immunity on the disease's development at the chronic phase has been known for many years. Given its impact on the virus’ transmission, analysis of the gut microbiota was naturally followed by analysis of the vaginal microbiota, And the studies have produced some compelling results. Here, as in other pathological situations, the question of how this microbiota could be modulated to impact the disease's development/acquisition is now being investigated, specifically by analysing the eating habits of a population of patients in which the obesity rate is steadily rising, as it is in the general population.

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Table of contents

Special Report

  • Microbiota and HIV/AIDSProf. Sophie Hüe, Prof. Jean-Daniel Lelièvre

Interview

  • Charles Cazanave

In Brief

The Microbiota Chronicle

Microbiota News

Taxonomic Reference

Contributors

Dossier thématiqueProf. Sophie Hüe, Prof. Jean-Daniel Lelièvre

1. Vaccine Research Institute, CHU Henri Mondor, 51 avenue Maréchal de Lattre de Tassigny, 94010 Créteil. 2. IMRB, équipe 16, CHU Henri Mondor, 51 avenue Maréchal de Lattre de Tassigny, 94010 Créteil. 3. UPEC, 8, rue du Général Sarrail 94010 Créteil Cedex. 4. Laboratoire d’immunologie biologique, CHU Henri Mondor, APHP, 51 avenue Maréchal de Lattre de Tassigny, 94010 Créteil. 5. Service d’immunologie clinique et maladies infectieuses, CHU Henri Mondor, APHP, 51 avenue Maréchal de Lattre de Tassigny, 94010 Créteil. E-mails: sophie.hue@aphp.fr; jean-daniel.lelievre@aphp.fr

EntretienProf. Charles Cazanave

Infectious and Tropical Diseases Department, National Reference Centre for Bacterial STIs, Bordeaux University Hospital Centre USC-EA 3671 Mycoplasma and Chlamydia Infections in Humans, Bordeaux University, France

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