Issue 10 march 2018 Special Report Gut microbiota and cancer treatments
The relationships between a host and their microbiota are associated with human diseases. Metabolic, cardiovascular, neurological, intestinal, pneumological and psychiatric diseases and cancers have all been associated with variations in gut microbiota, changes in the intestinal barrier and changes in bacterial translocation, whether this concerns the passage of live bacteria, fragments or bacterial metabolites.
Recent publications by French and American teams in the field of cancer immunotherapy have established association and causal links between the response to these innovative treatments and the microorganisms present in the intestine. They are paving the way to greater personalisation of oncology treatments and new treatment strategies based on control of the host-microbiota relationship.
In this regard we would like to thank Professor Franck Carbonnel from Kremlin-Bicêtre and Doctor Patricia Lepage from the INRA for agreeing to contribute to this issue and share their experience in this field. Their work is opening up new perspectives, as the variety of diet-, ageand geography-related gut microbiota is coming to represent a strong incentive for the invention of personalised medicine for the microbiota.
Table of contents
- Gut microbiota and cancer treatmentsFranck Carbonnel
- Vaginal dysbiosis and antiretroviralsJean-Marc Bohbot
- Rectal microbiota and HIV infectionJean-Marc Bohbot
- Intestinal bacterial translocation in lupus: an inflammation triggerJacques Amar
- Recolonising the nasopharynx of young infants with lactobacilli to prevent asthmaAlexis Mosca
- Improve asthma control by consuming more soluble fibre?Stanislas Bruley des Varannes
The Microbiota Chronicle
- Antibiotic therapy, microbiota and the future health of the newborn: dangerous liaisons…Thierry Harvey
- Patricia Lepage
Dossier thématiquePr Franck Carbonnel
Gastroenterology Department, Kremlin Bicêtre Hospital, Assistance Publique-Hôpitaux de Paris [Paris Hospital Authority], University of Paris Sud, Le Kremlin Bicêtre, France.
Chronique des microbiotesDr Thierry Harvey
Head of the Maternity Department, Diaconesses Croix Saint-Simon Hospital Group, Paris
EntretienDr Patricia Lepage
PhD, microbiologist and molecular ecologist, head of research within the Human Microbiome Psychology and Phylogeny team, Micalis Institute (Microbiology of Food for Health), INRA, Jouy-en-Josas.
Digestive Diseases Institute, Nantes.